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Gremlin 2 promotes differentiation of embryonic stem cells to atrial fate by activation of the JNK signaling pathway
The Bone Morphogenetic Protein antagonist Gremlin 2 (Grem2) is required for atrial differentiation and establishment of cardiac rhythm during embryonic development. A human Grem2 variant has been associated with familial atrial fibrillation, suggesting that abnormal Grem2 activity causes arrhythmias...
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| 主要な著者: | , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4123739/ https://ncbi.nlm.nih.gov/pubmed/24648383 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1703 |
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