HIV infection of dendritic cells subverts the IFN induction pathway via IRF-1 and inhibits type 1 IFN production

Many viruses have developed mechanisms to evade the IFN response. Here, HIV-1 was shown to induce a distinct subset of IFN-stimulated genes (ISGs) in monocyte-derived dendritic cells (DCs), without detectable type I or II IFN. These ISGs all contained an IFN regulatory factor 1 (IRF-1) binding site...

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Detalhes bibliográficos
Principais autores: Harman, Andrew N., Lai, Joey, Turville, Stuart, Samarajiwa, Shamith, Gray, Lachlan, Marsden, Valerie, Mercier, Sarah, Jones, Kate, Nasr, Najla, Rustagi, Arjun, Cumming, Helen, Donaghy, Heather, Mak, Johnson, Gale, Michael, Churchill, Melissa, Hertzog, Paul, Cunningham, Anthony L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4123420/
https://ncbi.nlm.nih.gov/pubmed/21411754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-07-297721
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