HIV infection of dendritic cells subverts the IFN induction pathway via IRF-1 and inhibits type 1 IFN production

Many viruses have developed mechanisms to evade the IFN response. Here, HIV-1 was shown to induce a distinct subset of IFN-stimulated genes (ISGs) in monocyte-derived dendritic cells (DCs), without detectable type I or II IFN. These ISGs all contained an IFN regulatory factor 1 (IRF-1) binding site...

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Bibliografske podrobnosti
Main Authors: Harman, Andrew N., Lai, Joey, Turville, Stuart, Samarajiwa, Shamith, Gray, Lachlan, Marsden, Valerie, Mercier, Sarah, Jones, Kate, Nasr, Najla, Rustagi, Arjun, Cumming, Helen, Donaghy, Heather, Mak, Johnson, Gale, Michael, Churchill, Melissa, Hertzog, Paul, Cunningham, Anthony L.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2011
Teme:
Immunobiology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4123420/
https://ncbi.nlm.nih.gov/pubmed/21411754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-07-297721
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