HIV-1–infected dendritic cells show 2 phases of gene expression changes, with lysosomal enzyme activity decreased during the second phase

Dendritic cells (DCs) play a key role in the pathogenesis of HIV infection. HIV interacts with these cells through 2 pathways in 2 temporal phases, initially via endocytosis and then via de novo replication. Here the transcriptional response of human DCs to HIV-1 was studied in these phases and at d...

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Autores principales: Harman, Andrew N., Kraus, Marianne, Bye, Chris R., Byth, Karen, Turville, Stuart G., Tang, Owen, Mercier, Sarah K., Nasr, Najla, Stern, Josh L., Slobedman, Barry, Driessen, Christoph, Cunningham, Anthony L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2009
Materias:
Immunobiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2710958/
https://ncbi.nlm.nih.gov/pubmed/19436054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-12-194845
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