The Microvesicle Component of HIV-1 Inocula Modulates Dendritic Cell Infection and Maturation and Enhances Adhesion to and Activation of T Lymphocytes

HIV-1 is taken up by immature monocyte derived dendritic cells (iMDDCs) into tetraspanin rich caves from which the virus can either be transferred to T lymphocytes or enter into endosomes resulting in degradation. HIV-1 binding and fusion with the DC membrane results in low level de novo infection t...

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Detalhes bibliográficos
Main Authors: Mercier, Sarah K., Donaghy, Heather, Botting, Rachel A., Turville, Stuart G., Harman, Andrew N., Nasr, Najla, Ji, Hong, Kusebauch, Ulrike, Mendoza, Luis, Shteynberg, David, Sandgren, Kerrie, Simpson, Richard J., Moritz, Robert L., Cunningham, Anthony L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3798598/
https://ncbi.nlm.nih.gov/pubmed/24204260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003700
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