RNF2 is recruited by WASH to ubiquitinate AMBRA1 leading to downregulation of autophagy

WASH (Wiskott-Aldrich syndrome protein (WASP) and SCAR homolog) was identified to function in endosomal sorting via Arp2/3 activation. We previously demonstrated that WASH is a new interactor of BECN1 and present in the BECN1-PIK3C3 complex with AMBRA1. The AMBRA1-DDB1-CUL4A complex is an E3 ligase...

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Detalhes bibliográficos
Main Authors: Xia, Pengyan, Wang, Shuo, Huang, Guanling, Du, Ying, Zhu, Pingping, Li, Man, Fan, Zusen
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4123297/
https://ncbi.nlm.nih.gov/pubmed/24980959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2014.85
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