Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice.

Surfactant protein B (SP-B) is an 8.7-kDa, hydrophobic protein that enhances the spreading and stability of surfactant phospholipids in the alveolus. To further assess the role of SP-B in lung function, the SP-B gene was disrupted by homologous recombination in murine mouse embryonic stem cells. Mic...

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Main Authors: Clark, J C, Wert, S E, Bachurski, C J, Stahlman, M T, Stripp, B R, Weaver, T E, Whitsett, J A
格式: Artigo
語言:Inglês
出版: 1995
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC41232/
https://ncbi.nlm.nih.gov/pubmed/7644495
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