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Altered surfactant homeostasis and recurrent respiratory failure secondary to TTF-1 nuclear targeting defect
BACKGROUND: Mutations of genes affecting surfactant homeostasis, such as SFTPB, SFTPC and ABCA3, lead to diffuse lung disease in neonates and children. Haploinsufficiency of NKX2.1, the gene encoding the thyroid transcription factor-1 (TTF-1) - critical for lung, thyroid and central nervous system m...
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| Main Authors: | , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
BioMed Central
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3179724/ https://ncbi.nlm.nih.gov/pubmed/21867529 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-12-115 |
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