Evidence for Soft Selective Sweeps in the Evolution of Pneumococcal Multidrug Resistance and Vaccine Escape

The multidrug-resistant Streptococcus pneumoniae Taiwan(19F)-14, or PMEN14, clone was first observed with a 19F serotype, which is targeted by the heptavalent polysaccharide conjugate vaccine (PCV7). However, “vaccine escape” PMEN14 isolates with a 19A serotype became an increasingly important cause...

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Autori principali: Croucher, Nicholas J., Chewapreecha, Claire, Hanage, William P., Harris, Simon R., McGee, Lesley, van der Linden, Mark, Song, Jae-Hoon, Ko, Kwan Soo, de Lencastre, Herminia, Turner, Claudia, Yang, Fan, Sá-Leão, Raquel, Beall, Bernard, Klugman, Keith P., Parkhill, Julian, Turner, Paul, Bentley, Stephen D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4122920/
https://ncbi.nlm.nih.gov/pubmed/24916661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gbe/evu120
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