Rapid pneumococcal evolution in response to clinical interventions

Epidemiological studies of the naturally transformable bacterial pathogen Streptococcus pneumoniae have previously been confounded by high rates of recombination. Sequencing 240 isolates of the PMEN1 (Spain(23F)-1) multidrug-resistant lineage enabled base substitutions to be distinguished from polym...

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Main Authors: Croucher, Nicholas J., Harris, Simon R., Fraser, Christophe, Quail, Michael A., Burton, John, van der Linden, Mark, McGee, Lesley, von Gottberg, Anne, Song, Jae Hoon, Ko, Kwan Soo, Pichon, Bruno, Baker, Stephen, Parry, Christopher M., Lambertsen, Lotte M., Shahinas, Dea, Pillai, Dylan R., Mitchell, Timothy J., Dougan, Gordon, Tomasz, Alexander, Klugman, Keith P., Parkhill, Julian, Hanage, William P., Bentley, Stephen D.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3648787/
https://ncbi.nlm.nih.gov/pubmed/21273480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1198545
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