Inhibitor of the Tyrosine Phosphatase STEP Reverses Cognitive Deficits in a Mouse Model of Alzheimer's Disease

STEP (STriatal-Enriched protein tyrosine Phosphatase) is a neuron-specific phosphatase that regulates N-methyl-D-aspartate receptor (NMDAR) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) trafficking, as well as ERK1/2, p38, Fyn, and Pyk2 activity. STEP is overactive in sev...

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Detaylı Bibliyografya
Asıl Yazarlar: Xu, Jian, Chatterjee, Manavi, Baguley, Tyler D., Brouillette, Jonathan, Kurup, Pradeep, Ghosh, Debolina, Kanyo, Jean, Zhang, Yang, Seyb, Kathleen, Ononenyi, Chimezie, Foscue, Ethan, Anderson, George M., Gresack, Jodi, Cuny, Gregory D., Glicksman, Marcie A., Greengard, Paul, Lam, TuKiet T., Tautz, Lutz, Nairn, Angus C., Ellman, Jonathan A., Lombroso, Paul J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2014
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4122355/
https://ncbi.nlm.nih.gov/pubmed/25093460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1001923
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