EDEM2 initiates mammalian glycoprotein ERAD by catalyzing the first mannose trimming step

Glycoproteins misfolded in the endoplasmic reticulum (ER) are subjected to ER-associated glycoprotein degradation (gpERAD) in which Htm1-mediated mannose trimming from the oligosaccharide Man(8)GlcNAc(2) to Man(7)GlcNAc(2) is the rate-limiting step in yeast. In contrast, the roles of the three Htm1...

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Main Authors: Ninagawa, Satoshi, Okada, Tetsuya, Sumitomo, Yoshiki, Kamiya, Yukiko, Kato, Koichi, Horimoto, Satoshi, Ishikawa, Tokiro, Takeda, Shunichi, Sakuma, Tetsushi, Yamamoto, Takashi, Mori, Kazutoshi
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2014
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121980/
https://ncbi.nlm.nih.gov/pubmed/25092655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201404075
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