Arhgap36-dependent activation of Gli transcription factors

Hedgehog (Hh) pathway activation and Gli-dependent transcription play critical roles in embryonic patterning, tissue homeostasis, and tumorigenesis. By conducting a genome-scale cDNA overexpression screen, we have identified the Rho GAP family member Arhgap36 as a positive regulator of the Hh pathwa...

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Autori principali: Rack, Paul G., Ni, Jun, Payumo, Alexander Y., Nguyen, Vien, Crapster, J. Aaron, Hovestadt, Volker, Kool, Marcel, Jones, David T. W., Mich, John K., Firestone, Ari J., Pfister, Stefan M., Cho, Yoon-Jae, Chen, James K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2014
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121843/
https://ncbi.nlm.nih.gov/pubmed/25024229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1322362111
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