Pla2g16 phospholipase mediates gain-of-function activities of mutant p53

p53(R172H/+) mice inherit a p53 mutation found in Li-Fraumeni syndrome and develop metastatic tumors at much higher frequency than p53(+/−) mice. To explore the mutant p53 metastatic phenotype, we used expression arrays to compare primary osteosarcomas from p53(R172H/+) mice with metastasis to osteo...

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Detalhes bibliográficos
Main Authors: Xiong, Shunbin, Tu, Huolin, Kollareddy, Madhusudhan, Pant, Vinod, Li, Qin, Zhang, Yun, Jackson, James G., Suh, Young-Ah, Elizondo-Fraire, Ana C., Yang, Peirong, Chau, Gilda, Tashakori, Mehrnoosh, Wasylishen, Amanda R., Ju, Zhenlin, Solomon, Hilla, Rotter, Varda, Liu, Bin, El-Naggar, Adel K., Donehower, Lawrence A., Martinez, Luis Alfonso, Lozano, Guillermina
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121829/
https://ncbi.nlm.nih.gov/pubmed/25024203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1404139111
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