Somatic Trp53 mutations differentially drive breast cancer and evolution of metastases

TP53 mutations are the most frequent genetic alterations in breast cancer and are associated with more aggressive disease and worse overall survival. We have created two conditional mutant Trp53 alleles in the mouse that allow expression of Trp53R172H or Trp53R245W missense mutations in single cells...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Zhang, Yun, Xiong, Shunbin, Liu, Bin, Pant, Vinod, Celii, Francis, Chau, Gilda, Elizondo-Fraire, Ana C., Yang, Peirong, You, Mingjian James, El-Naggar, Adel K., Navin, Nicholas E., Lozano, Guillermina
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6160420/
https://ncbi.nlm.nih.gov/pubmed/30262850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06146-9
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