Somatic Trp53 mutations differentially drive breast cancer and evolution of metastases

TP53 mutations are the most frequent genetic alterations in breast cancer and are associated with more aggressive disease and worse overall survival. We have created two conditional mutant Trp53 alleles in the mouse that allow expression of Trp53R172H or Trp53R245W missense mutations in single cells...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Zhang, Yun, Xiong, Shunbin, Liu, Bin, Pant, Vinod, Celii, Francis, Chau, Gilda, Elizondo-Fraire, Ana C., Yang, Peirong, You, Mingjian James, El-Naggar, Adel K., Navin, Nicholas E., Lozano, Guillermina
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6160420/
https://ncbi.nlm.nih.gov/pubmed/30262850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06146-9
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