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Predictive energy landscapes for folding α-helical transmembrane proteins

We explore the hypothesis that the folding landscapes of membrane proteins are funneled once the proteins’ topology within the membrane is established. We extend a protein folding model, the associative memory, water-mediated, structure, and energy model (AWSEM) by adding an implicit membrane potent...

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Autors principals: Kim, Bobby L., Schafer, Nicholas P., Wolynes, Peter G.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121805/
https://ncbi.nlm.nih.gov/pubmed/25030446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1410529111
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