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Absence of lipofuscin in motor neurons of SOD1-linked ALS mice

Lipofuscin, or aging pigment, is accreted as red autofluorescence in the lysosomes of motor neuron cell bodies in the ventral horn of WT mice by 3 mo of age. Strikingly, in two presymptomatic ALS mouse strains transgenic for mutant human Cu/Zn superoxide dismutase (SOD1), G85R SOD1YFP and G93A SOD1,...

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Bibliografski detalji
Glavni autori: Bandyopadhyay, Urmi, Nagy, Maria, Fenton, Wayne A., Horwich, Arthur L.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121794/
https://ncbi.nlm.nih.gov/pubmed/25024188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1409314111
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