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Impaired excitability of somatostatin- and parvalbumin-expressing cortical interneurons in a mouse model of Dravet syndrome

Haploinsufficiency of the voltage-gated sodium channel Na(V)1.1 causes Dravet syndrome, an intractable developmental epilepsy syndrome with seizure onset in the first year of life. Specific heterozygous deletion of Na(V)1.1 in forebrain GABAergic-inhibitory neurons is sufficient to cause all the man...

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Bibliografische gegevens
Hoofdauteurs: Tai, Chao, Abe, Yasuyuki, Westenbroek, Ruth E., Scheuer, Todd, Catterall, William A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121787/
https://ncbi.nlm.nih.gov/pubmed/25024183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1411131111
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