Decreased dopamine brain reactivity in marijuana abusers is associated with negative emotionality and addiction severity

Moves to legalize marijuana highlight the urgency to investigate effects of chronic marijuana in the human brain. Here, we challenged 48 participants (24 controls and 24 marijuana abusers) with methylphenidate (MP), a drug that elevates extracellular dopamine (DA) as a surrogate for probing the reac...

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Bibliographic Details
Main Authors: Volkow, Nora D., Wang, Gene-Jack, Telang, Frank, Fowler, Joanna S., Alexoff, David, Logan, Jean, Jayne, Millard, Wong, Christopher, Tomasi, Dardo
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2014
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121778/
https://ncbi.nlm.nih.gov/pubmed/25024177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1411228111
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