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Decreased dopamine brain reactivity in marijuana abusers is associated with negative emotionality and addiction severity

Moves to legalize marijuana highlight the urgency to investigate effects of chronic marijuana in the human brain. Here, we challenged 48 participants (24 controls and 24 marijuana abusers) with methylphenidate (MP), a drug that elevates extracellular dopamine (DA) as a surrogate for probing the reac...

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Autors principals: Volkow, Nora D., Wang, Gene-Jack, Telang, Frank, Fowler, Joanna S., Alexoff, David, Logan, Jean, Jayne, Millard, Wong, Christopher, Tomasi, Dardo
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121778/
https://ncbi.nlm.nih.gov/pubmed/25024177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1411228111
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