SMAD3 augments FoxO3-induced MuRF-1 promoter activity in a DNA-binding-dependent manner

Muscle-specific RING finger-1 (MuRF-1), a ubiquitin ligase and key regulator of proteasome-dependent protein degradation, is highly expressed during skeletal muscle atrophy. The transcription factor forkhead box O3 (FoxO3) induces MuRF-1 expression, but the direct role of other major atrophy-related...

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Hauptverfasser: Bollinger, Lance M., Witczak, Carol A., Houmard, Joseph A., Brault, Jeffrey J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2014
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121583/
https://ncbi.nlm.nih.gov/pubmed/24920680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00391.2013
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