A Conserved Target Site in HIV-1 Gag RNA is Accessible to Inhibition by Both an HDV Ribozyme and a Short Hairpin RNA

Antisense-based molecules targeting HIV-1 RNA have the potential to be used as part of gene or drug therapy to treat HIV-1 infection. In this study, HIV-1 RNA was screened to identify more conserved and accessible target sites for ribozymes based on the hepatitis delta virus motif. Using a quantitat...

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Detalhes bibliográficos
Main Authors: Scarborough, Robert J, Lévesque, Michel V, Boudrias-Dalle, Etienne, Chute, Ian C, Daniels, Sylvanne M, Ouellette, Rodney J, Perreault, Jean-Pierre, Gatignol, Anne
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121520/
https://ncbi.nlm.nih.gov/pubmed/25072692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2014.31
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