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L-Carnitine Protects against Carboplatin-Mediated Renal Injury: AMPK- and PPARα-Dependent Inactivation of NFAT3

We have previously shown that carboplatin induces inflammation and apoptosis in renal tubular cells (RTCs) through the activation of the nuclear factor of activated T cells-3 (NFAT3) protein by reactive oxygen species (ROS), and that the ROS-mediated activation of NFAT3 is prevented by N-acetyl cyst...

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Bibliografiske detaljer
Main Authors: Sue, Yuh-Mou, Chou, Hsiu-Chu, Chang, Chih-Cheng, Yang, Nian-Jie, Chou, Ying, Juan, Shu-Hui
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121315/
https://ncbi.nlm.nih.gov/pubmed/25090113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0104079
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