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Prion (PrPC) Expression in Ovine Uteroplacental Tissues Increases after Estrogen-treatment in Ovariectomized (OVX) Ewes and during Early Pregnancy

Scrapie in sheep is spread laterally by placental transmission of an infectious misfolded form (PrPSc) of a normal prion protein (PrPC) used as a template in PrPSc formation. We hypothesized that PrPC would be expressed in uterine and placental tissues and estradiol-17B (E2) would affect uterine PrP...

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Bibliografiske detaljer
Main Authors: Johnson, Mary Lynn, Grazul-Bilska, Anna T., Reynolds, Lawrence P., Redmer, Dale A.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121124/
https://ncbi.nlm.nih.gov/pubmed/24664411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/REP-13-0548
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