α(1)-Antitrypsin Therapy Downregulates Toll-Like Receptor-Induced IL-1β Responses in Monocytes and Myeloid Dendritic Cells and May Improve Islet Function in Recently Diagnosed Patients With Type 1 Diabetes

CONTEXT: Recent studies have implicated proinflammatory responses in the mechanism of type 1 diabetes (T1D). OBJECTIVE: Our objective was to evaluate the safety and effects of therapy with the anti-inflammatory serum protein α(1)-antitrypsin (AAT) on islet function and innate immunity in recent-onse...

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Detalhes bibliográficos
Main Authors: Gottlieb, Peter A., Alkanani, Aimon K., Michels, Aaron W., Lewis, Eli C., Shapiro, Leland, Dinarello, Charles A., Zipris, Danny
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2014
Assuntos:
Hot Topics in Translational Endocrinology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121034/
https://ncbi.nlm.nih.gov/pubmed/24527714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2013-3864
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