Bone Mineral Content in Patients With Congenital Generalized Lipodystrophy Is Unaffected by Metreleptin Replacement Therapy

CONTEXT: Leptin alters bone and mineral metabolism in rodents, but this has not been verified in humans. Patients with congenital generalized lipodystrophy (CGL) have low leptin due to deficient adipose mass and serve as models of leptin deficiency and replacement. OBJECTIVE: To study the effects of...

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書誌詳細
主要な著者: Christensen, John D., Lungu, Andreea O., Cochran, Elaine, Collins, Michael T., Gafni, Rachel I., Reynolds, James C., Rother, Kristina I., Gorden, Phillip, Brown, Rebecca J.
フォーマット: Artigo
言語:Inglês
出版事項: Endocrine Society 2014
主題:
JCEM Online: Advances in Genetics
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121033/
https://ncbi.nlm.nih.gov/pubmed/25070319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2014-1353
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