Bone Mineral Content in Patients With Congenital Generalized Lipodystrophy Is Unaffected by Metreleptin Replacement Therapy

CONTEXT: Leptin alters bone and mineral metabolism in rodents, but this has not been verified in humans. Patients with congenital generalized lipodystrophy (CGL) have low leptin due to deficient adipose mass and serve as models of leptin deficiency and replacement. OBJECTIVE: To study the effects of...

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Main Authors: Christensen, John D., Lungu, Andreea O., Cochran, Elaine, Collins, Michael T., Gafni, Rachel I., Reynolds, James C., Rother, Kristina I., Gorden, Phillip, Brown, Rebecca J.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2014
Assuntos:
JCEM Online: Advances in Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121033/
https://ncbi.nlm.nih.gov/pubmed/25070319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2014-1353
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