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Ipsen 5i is a Novel Potent Pharmacoperone for Intracellularly Retained Melanocortin-4 Receptor Mutants

Inactivating mutations of the melanocortin-4 receptor (MC4R) cause early-onset severe obesity in humans. Comprehensive functional studies show that most of the inactivating mutants of the MC4R are retained intracellularly. In the present study, we investigated whether a small molecule inverse agonis...

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Detalhes bibliográficos
Main Authors: Tao, Ya-Xiong, Huang, Hui
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4120685/
https://ncbi.nlm.nih.gov/pubmed/25136332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fendo.2014.00131
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