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Modeling sequence and function similarity between proteins for protein functional annotation

A common task in biological research is to predict function for proteins by comparing sequences between proteins of known and unknown function. This is often done using pair-wise sequence alignment algorithms (e.g. BLAST). A problem with this approach is the assumption of a simple equivalence betwee...

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Detalhes bibliográficos
Main Authors: Higdon, Roger, Louie, Brenton, Kolker, Eugene
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4120521/
https://ncbi.nlm.nih.gov/pubmed/25101328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1145/1851476.1851548
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