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A Statistical Model of Protein Sequence Similarity and Function Similarity Reveals Overly-Specific Function Predictions

BACKGROUND: Predicting protein function from primary sequence is an important open problem in modern biology. Not only are there many thousands of proteins of unknown function, current approaches for predicting function must be improved upon. One problem in particular is overly-specific function pre...

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Bibliografiska uppgifter
Huvudupphovsmän: Louie, Brenton, Higdon, Roger, Kolker, Eugene
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2009
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2760442/
https://ncbi.nlm.nih.gov/pubmed/19844580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007546
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