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A Statistical Model of Protein Sequence Similarity and Function Similarity Reveals Overly-Specific Function Predictions

BACKGROUND: Predicting protein function from primary sequence is an important open problem in modern biology. Not only are there many thousands of proteins of unknown function, current approaches for predicting function must be improved upon. One problem in particular is overly-specific function pre...

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Detalhes bibliográficos
Main Authors: Louie, Brenton, Higdon, Roger, Kolker, Eugene
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2760442/
https://ncbi.nlm.nih.gov/pubmed/19844580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007546
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