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Identification of small molecules inhibiting diguanylate cyclases to control bacterial biofilm development

Biofilm formation by pathogenic bacteria is an important virulence factor in the development of numerous chronic infections, thereby causing a severe health burden. Many of these infections cannot be resolved, as bacteria in biofilms are resistant to the host’s immune defenses and antibiotic therapy...

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Autors principals: Sambanthamoorthy, Karthik, Luo, Chunyuan, Pattabiraman, Nagarajan, Feng, Xiarong, Koestler, Benjamin, Waters, Christopher M., Palys, Thomas J.
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4120261/
https://ncbi.nlm.nih.gov/pubmed/24117391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/08927014.2013.832224
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