Identification of acquired mutations by whole-genome sequencing in GATA-2 deficiency evolving into myelodysplasia and acute leukemia

Heterozygous GATA-2 germline mutations are associated with overlapping clinical manifestations termed GATA-2 deficiency, characterized by immunodeficiency and predisposition to myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). However, there is considerable clinical heterogeneity amon...

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Main Authors: Fujiwara, Tohru, Fukuhara, Noriko, Funayama, Ryo, Nariai, Naoki, Kamata, Mayumi, Nagashima, Takeshi, Kojima, Kaname, Onishi, Yasushi, Sasahara, Yoji, Ishizawa, Kenichi, Nagasaki, Masao, Nakayama, Keiko, Harigae, Hideo
Formato: Artigo
Idioma:Inglês
Publicado: Springer Berlin Heidelberg 2014
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4119934/
https://ncbi.nlm.nih.gov/pubmed/24782121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00277-014-2090-4
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