Local Packing Density Is the Main Structural Determinant of the Rate of Protein Sequence Evolution at Site Level

Functional and biophysical constraints result in site-dependent patterns of protein sequence variability. It is commonly assumed that the key structural determinant of site-specific rates of evolution is the Relative Solvent Accessibility (RSA). However, a recent study found that amino acid substitu...

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Autors principals: Yeh, So-Wei, Huang, Tsun-Tsao, Liu, Jen-Wei, Yu, Sung-Huan, Shih, Chien-Hua, Hwang, Jenn-Kang, Echave, Julian
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4119917/
https://ncbi.nlm.nih.gov/pubmed/25121105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/572409
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