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Origins of the specificity of tissue-type plasminogen activator.

The role of subsite interactions in defining the stringent substrate specificity of tissue-type plasminogen activator (t-PA) has been examined by using an fd phage library that displayed random hexapeptide sequences and contained 2 x 10(8) independent recombinants. Forty-four individual hexapeptides...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Ding, L, Coombs, G S, Strandberg, L, Navre, M, Corey, D R, Madison, E L
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 1995
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Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41198/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7644467/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.17.7627
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