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The Ability to Rearrange Dual TCRs Enhances Positive Selection, Leading to Increased Allo- and Autoreactive T Cell Repertoires
Thymic selection is designed to ensure T cell receptor (TCR) reactivity to foreign antigens presented by self-MHC while minimizing reactivity to self-antigens. We hypothesized that the repertoire of T cells with unwanted specificities such as alloreactivity or autoreactivity are a consequence of sim...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4119549/ https://ncbi.nlm.nih.gov/pubmed/25015825 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400532 |
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