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The Ability to Rearrange Dual TCRs Enhances Positive Selection, Leading to Increased Allo- and Autoreactive T Cell Repertoires

Thymic selection is designed to ensure T cell receptor (TCR) reactivity to foreign antigens presented by self-MHC while minimizing reactivity to self-antigens. We hypothesized that the repertoire of T cells with unwanted specificities such as alloreactivity or autoreactivity are a consequence of sim...

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Detalhes bibliográficos
Main Authors: Ni, Peggy P., Solomon, Benjamin, Hsieh, Chyi-Song, Allen, Paul M., Morris, Gerald P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4119549/
https://ncbi.nlm.nih.gov/pubmed/25015825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1400532
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