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Alloreactivity is limited by the endogenous peptide repertoire
A significant portion of the naive T-cell repertoire is capable of responding to allogeneic MHC, violating the paradigm of self-MHC restriction. Recent studies have demonstrated convincing evidence for germ-line affinity of T-cell receptors (TCR) for MHC, providing explanation for recognition of MHC...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3048116/ https://ncbi.nlm.nih.gov/pubmed/21321209 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1017015108 |
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