Genetic Modification of T Cells Redirected towards CS1 Enhances Eradication of Myeloma Cells

PURPOSE: Our goal is to test if CS1 could be targeted by CAR T cells to treat MM. EXPERIMENTAL DESIGN: We generated a retroviral construct of a CS1-specific CAR and engineered primary human T cells expressing the CAR. We then tested the capacity of CS1-CAR T cells to eradicate human multiple myeloma...

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Hlavní autoři: Chu, Jianhong, He, Shun, Deng, Youcai, Zhang, Jianying, Peng, Yong, Hughes, Tiffany, Yi, Ling, Kwon, Chang-Hyuk, Wang, Qi-En, Devine, Steven M, He, Xiaoming, Bai, Xue-Feng, Hofmeister, Craig C., Yu, Jianhua
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4119545/
https://ncbi.nlm.nih.gov/pubmed/24677374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-2510
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