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Mapping the conformational space accessible to catechol-O-methyltransferase
Methylation catalysed by catechol-O-methyltransferase (COMT) is the main pathway of catechol neurotransmitter deactivation in the prefrontal cortex. Low levels of this class of neurotransmitters are held to be causative of diseases such as schizophrenia, depression and Parkinson’s disease. Inhibitio...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
International Union of Crystallography
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4118827/ https://ncbi.nlm.nih.gov/pubmed/25084335 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1399004714012917 |
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