Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step

Aerobic glycolysis or the Warburg Effect (WE) is characterized by the increased metabolism of glucose to lactate. It remains unknown what quantitative changes to the activity of metabolism are necessary and sufficient for this phenotype. We developed a computational model of glycolysis and an integr...

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מידע ביבליוגרפי
Main Authors: Shestov, Alexander A, Liu, Xiaojing, Ser, Zheng, Cluntun, Ahmad A, Hung, Yin P, Huang, Lei, Kim, Dongsung, Le, Anne, Yellen, Gary, Albeck, John G, Locasale, Jason W
פורמט: Artigo
שפה:Inglês
יצא לאור: eLife Sciences Publications, Ltd 2014
נושאים:
Biochemistry
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4118620/
https://ncbi.nlm.nih.gov/pubmed/25009227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.03342
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