Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step

Aerobic glycolysis or the Warburg Effect (WE) is characterized by the increased metabolism of glucose to lactate. It remains unknown what quantitative changes to the activity of metabolism are necessary and sufficient for this phenotype. We developed a computational model of glycolysis and an integr...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Shestov, Alexander A, Liu, Xiaojing, Ser, Zheng, Cluntun, Ahmad A, Hung, Yin P, Huang, Lei, Kim, Dongsung, Le, Anne, Yellen, Gary, Albeck, John G, Locasale, Jason W
Materialtyp: Artigo
Språk:Inglês
Publicerad: eLife Sciences Publications, Ltd 2014
Ämnen:
Biochemistry
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4118620/
https://ncbi.nlm.nih.gov/pubmed/25009227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.03342
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk