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Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity
Activated immune cells undergo a metabolic switch to aerobic glycolysis akin to the Warburg effect, presenting a potential therapeutic target in autoimmune disease. Dimethyl fumarate, a derivative of the Krebs cycle intermediate fumarate, is an immunomodulatory drug used to treat multiple sclerosis...
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| Publicado no: | Science |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5924419/ https://ncbi.nlm.nih.gov/pubmed/29599194 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aan4665 |
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