Chondroitin Sulfate Promotes Activation of Cathepsin K

Cathepsin K (CatK), a major lysosomal collagenase produced by osteoclasts, plays an important role in bone resorption. Evidence exists that the collagenase activity of CatK is promoted by chondroitin sulfate (CS), a sulfated glycosaminoglycan. This study examines the role of CS in facilitating CatK...

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Bibliographische Detailangaben
Hauptverfasser: Lemaire, Peter A., Huang, Lingyi, Zhuo, Ya, Lu, Jun, Bahnck, Carolyn, Stachel, Shawn J., Carroll, Steve S., Duong, Le T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
Enzymology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4118116/
https://ncbi.nlm.nih.gov/pubmed/24958728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.559898
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