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Elevated Sensitivity of Macrosteatotic Hepatocytes to Hypoxia-Reoxygenation Stress Is Reversed by a Novel Defatting Protocol

Macrosteatotic livers exhibit elevated intrahepatic triglyceride (TG) content in the form of large lipid droplets (LDs), reduced ATP, and elevated reactive oxygen species (ROS), contributing to their elevated sensitivity to ischemia-reperfusion injury during transplantation. Decreasing macrosteatosi...

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書誌詳細
主要な著者: Nativ, Nir I., Yarmush, Gabriel, So, Ashley, Barminko, Jeffery, Maguire, Timothy J., Schloss, Rene, Berthiaume, Francois, Yarmush, Martin L.
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4117728/
https://ncbi.nlm.nih.gov/pubmed/24802973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/lt.23905
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