Elevated Sensitivity of Macrosteatotic Hepatocytes to Hypoxia-Reoxygenation Stress Is Reversed by a Novel Defatting Protocol

Macrosteatotic livers exhibit elevated intrahepatic triglyceride (TG) content in the form of large lipid droplets (LDs), reduced ATP, and elevated reactive oxygen species (ROS), contributing to their elevated sensitivity to ischemia-reperfusion injury during transplantation. Decreasing macrosteatosi...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Nativ, Nir I., Yarmush, Gabriel, So, Ashley, Barminko, Jeffery, Maguire, Timothy J., Schloss, Rene, Berthiaume, Francois, Yarmush, Martin L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4117728/
https://ncbi.nlm.nih.gov/pubmed/24802973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/lt.23905
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