Elevated Sensitivity of Macrosteatotic Hepatocytes to Hypoxia-Reoxygenation Stress Is Reversed by a Novel Defatting Protocol

Macrosteatotic livers exhibit elevated intrahepatic triglyceride (TG) content in the form of large lipid droplets (LDs), reduced ATP, and elevated reactive oxygen species (ROS), contributing to their elevated sensitivity to ischemia-reperfusion injury during transplantation. Decreasing macrosteatosi...

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Main Authors: Nativ, Nir I., Yarmush, Gabriel, So, Ashley, Barminko, Jeffery, Maguire, Timothy J., Schloss, Rene, Berthiaume, Francois, Yarmush, Martin L.
格式: Artigo
語言:Inglês
出版: 2014
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4117728/
https://ncbi.nlm.nih.gov/pubmed/24802973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/lt.23905
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