Human APOBEC3 Induced Mutation of Human Immunodeficiency Virus Type-1 Contributes to Adaptation and Evolution in Natural Infection

Human APOBEC3 proteins are cytidine deaminases that contribute broadly to innate immunity through the control of exogenous retrovirus replication and endogenous retroelement retrotransposition. As an intrinsic antiretroviral defense mechanism, APOBEC3 proteins induce extensive guanosine-to-adenosine...

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Detalhes bibliográficos
Main Authors: Kim, Eun-Young, Lorenzo-Redondo, Ramon, Little, Susan J., Chung, Yoon-Seok, Phalora, Prabhjeet K., Maljkovic Berry, Irina, Archer, John, Penugonda, Sudhir, Fischer, Will, Richman, Douglas D., Bhattacharya, Tanmoy, Malim, Michael H., Wolinsky, Steven M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4117599/
https://ncbi.nlm.nih.gov/pubmed/25080100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004281
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