MUC1 Positive, Kras and Pten Driven Mouse Gynecologic Tumors Replicate Human Tumors and Vary in Survival and Nuclear Grade Based on Anatomical Location

Activating mutations of Kras oncogene and deletions of Pten tumor suppressor gene play important roles in cancers of the female genital tract. We developed here new preclinical models for gynecologic cancers, using conditional (Cre-loxP) mice with floxed genetic alterations in Kras and Pten. The tri...

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Detalhes bibliográficos
Main Authors: Tirodkar, Tejas S., Budiu, Raluca A., Elishaev, Esther, Zhang, Lixin, Mony, Jyothi T., Brozick, Joan, Edwards, Robert P., Vlad, Anda M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4117479/
https://ncbi.nlm.nih.gov/pubmed/25078979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0102409
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