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Hotspot Mutations in KIT Receptor Differentially Modulate Its Allosterically Coupled Conformational Dynamics: Impact on Activation and Drug Sensitivity

Receptor tyrosine kinase KIT controls many signal transduction pathways and represents a typical allosterically regulated protein. The mutation-induced deregulation of KIT activity impairs cellular physiological functions and causes serious human diseases. The impact of hotspots mutations (D816H/Y/N...

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Bibliografski detalji
Glavni autori: Chauvot de Beauchêne, Isaure, Allain, Ariane, Panel, Nicolas, Laine, Elodie, Trouvé, Alain, Dubreuil, Patrice, Tchertanov, Luba
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4117417/
https://ncbi.nlm.nih.gov/pubmed/25079768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003749
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