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The First 3D Model of the Full-Length KIT Cytoplasmic Domain Reveals a New Look for an Old Receptor

Receptor tyrosine kinases (RTKs) are key regulators of normal cellular processes and have a critical role in the development and progression of many diseases. RTK ligand-induced stimulation leads to activation of the cytoplasmic kinase domain that controls the intracellular signalling. Although the...

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Podrobná bibliografie
Vydáno v:Sci Rep
Hlavní autoři: Inizan, François, Hanna, Myriam, Stolyarchuk, Maxim, Chauvot de Beauchêne, Isaure, Tchertanov, Luba
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7096506/
https://ncbi.nlm.nih.gov/pubmed/32214210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-62460-7
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