Carbohydrate-Based Ice Recrystallization Inhibitors Increase Infectivity and Thermostability of Viral Vectors

The inability of vaccines to retain sufficient thermostability has been an obstacle to global vaccination programs. To address this major limitation, we utilized carbohydrate-based ice recrystallization inhibitors (IRIs) to eliminate the cold chain and stabilize the potency of Vaccinia virus (VV), V...

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Main Authors: Ghobadloo, Shahrokh M., Balcerzak, Anna K., Gargaun, Ana, Muharemagic, Darija, Mironov, Gleb G., Capicciotti, Chantelle J., Briard, Jennie G., Ben, Robert N., Berezovski, Maxim V.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4116624/
https://ncbi.nlm.nih.gov/pubmed/25078058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep05903
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