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Selective PPARγ modulator INT131 normalizes insulin signaling defects and improves bone mass in diet-induced obese mice
INT131 is a potent non-thiazolidinedione (TZD)-selective peroxisome proliferator-activated receptor-γ modulator being developed for the treatment of type 2 diabetes. In preclinical studies and a phase II clinical trial, INT131 has been shown to lower glucose levels and ameliorate insulin resistance...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Physiological Society
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4116349/ https://ncbi.nlm.nih.gov/pubmed/22215652 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00569.2011 |
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